Value of ion channel genes in epilepsy treatment
10.3760/cma.j.cn115354-20231016-00167
- VernacularTitle:离子通道基因在癫痫治疗中的价值
- Author:
Wenjie HAN
1
;
Zhensheng LI
;
Jianjie KANG
;
Bingmei DENG
Author Information
1. 中国人民解放军南部战区总医院神经内科，广州 510010
- Keywords:
Epilepsy;
Treatment;
Ion channel gene;
Cardio-brain channel disease;
Antisense oligonucleotide
- From:
Chinese Journal of Neuromedicine
2024;23(3):240-245
- CountryChina
- Language:Chinese
-
Abstract:
By gene sequencing methods, such as targeted sequencing, whole exome sequencing (WES) and whole genome sequencing (WGS), about 1,000 epilepsy-related genes have been identified recently; and ion channel related genes are the most common genes being studied; about 25% single-gene inherited epilepsy is associated with ion channel gene variants. This article reviews the value of ion channel genes in epilepsy treatment so as to improve the understanding of epilepsy related ion channel genes and further optimize the treatment strategy of epilepsy.
