Recent advance in risk factors related to restless leg syndrome

VernacularTitle:不宁腿综合征发病相关的风险因素研究进展
Author: Baoyan WANG ¹ ; Jie WU ; Duanyang LI ; Ruilin ZHANG ; Rong XUE ; Wei WU
Author Information

1. 天津医科大学总医院空港医院神经内科，天津　300308
Keywords: Restless legs syndrome; Risk factor; Genetic factor; Non-genetic factor; Pathogenesis
From: Chinese Journal of Neuromedicine 2024;23(2):208-216
CountryChina
Language:Chinese
Abstract: Restless legs syndrome (RLS) is a common sensorimotor disorder. Although it does not pose a threat to life, it seriously affects the quality of life of patients. RLS pathogenesis is still unclear, and its incidence is associated with a variety of risk factors, including genetic factors and non-genetic factors. Genetic factors involve more than 20 risk genes, such as meis homeobox 1 ( MEIS1), BTB domain containing 9 ( BTBD9), mitogen-activated protein kinase kinase 5 ( MAP2K5), and protein tyrosine phosphatase receptor type Db ( PTPRD). Non-genetic factors include regional age, gender, obesity, medical related diseases, neuropsychiatric diseases and drugs. This paper reviews the recent advance in risk factors and related pathogenesis of RLS to provide references for early prevention and treatment of the disease.