Recent advance in role of stromal interaction molecule 1 in ischemic stroke

VernacularTitle:基质相互作用分子1在缺血性脑卒中的研究进展
Author: Ruixin LI ¹ ; Gang SU ; Ya WANG ; Minghui SHEN ; Longni ZHU ; Zhenchang ZHANG
Author Information

1. 兰州大学第二医院神经内科，兰州　730030
Keywords: Stromal interaction molecule 1; Ischemic stroke; Mechanism; Treatment; Prognosis
From: Chinese Journal of Neuromedicine 2024;23(2):192-196
CountryChina
Language:Chinese
Abstract: Stromal interaction molecule 1 (STIM1) is a key component mediating store-operated calcium entry (SOCE), which controls the opening and closing of plasma membrane Ca 2+ channels by sensing the Ca 2+ content of endoplasmic reticulum luminal stores, and thus affects the processes of cell adhesion, migration, gene expression and proliferation. Studies have shown that STIM1 is abnormally expressed in a variety of cells such as neurons, endothelial cells and platelets during ischemic stroke (IS) development; it plays an important role in the pathological processes regulating hypertension, promoting thrombosis, activating cellular autophagy, mediating apoptosis and promoting neuroinflammation. This review summarizes the research progress of STIM1 in the development and prognostic assessment of IS, and seeks to provide theoretical references for potential therapeutic targets for IS.