Role of thrombomodulin-thrombin-high mobility group box 1 pathway in chronic subdural hematoma

VernacularTitle:血栓调节素-凝血酶-高迁移率族蛋白1通路在慢性硬膜下血肿发生发展中的作用研究进展
Author: Zejun WU ¹ ; Junshuang ZHAO ; Juntao HU
Author Information

1. 锦州医科大学研究生院，锦州　121000
Keywords: Chronic subdural hematoma; Thrombomodulin; Thrombin; High mobility group box-1
From: Chinese Journal of Neuromedicine 2024;23(2):181-185
CountryChina
Language:Chinese
Abstract: Chronic subdural hematoma (CSDH) is a collection of blood, blood clots and their degradation products, encapsulated by membrane and located within dural border cell layer. Pathophysiological processes such as inflammatory responses within hematoma cavity, coagulation abnormalities, and abnormalities in neovascularization play significant roles in CSDH development. High mobility group box 1 (HMGB1) can mediate processes such as inflammation, angiogenesis, and hemostasis, while thrombomodulin (TM) can bind with HMGB1 and rely on thrombin to degrade HMGB1. Current research has confirmed that the expressions of TM, HMGB1, and their downstream related factors are abnormally increased in the hematoma fluid of CSDH; however, the role of TM-thrombin-HMGB1 pathway in CSDH development is not fully clear. This article reviews the role of TM-thrombin-HMGB1 pathway in CSDH development, aiming to provide some references for pathogenesis and new therapeutic targets of CSDH.