Recent advance in pathogenesis and treatments of neurological complications related to patent foramen ovale
10.3760/cma.j.cn115354-20221203-00882
- VernacularTitle:卵圆孔未闭相关神经系统并发症发病机制及治疗研究进展
- Author:
Aoxue WANG
1
;
Yihan TANG
;
Ruiqi SANG
;
Zhiyong WU
;
Yongle RUAN
Author Information
1. 武汉大学人民医院心血管外科，武汉 430060
- Keywords:
Patent foramen ovale;
Migraine;
Cryptogenic stroke;
Depression;
Alzheimer's disease
- From:
Chinese Journal of Neuromedicine
2023;22(12):1282-1286
- CountryChina
- Language:Chinese
-
Abstract:
Patent foramen ovale (PFO) is the most prevalent congenital heart disease, often accompanied by neurological symptoms as migraine, unexplained dizziness, and even anxiety and depression. Recent research findings indicate that the pathogenesis of neurological complications related to PFO involves abnormal embolism hypothesis, vasoactive substance hypothesis, impaired cerebral blood flow regulation and genetic inheritance. Treatments include primarily encompass pharmacological intervention and foramen ovale occlusion. This article summarizes the aforementioned research progress in order to provide clinical guidance for managing nervous system complications related to PFO.
