Recent advance in role of copper homeostasis and copper death in central nervous system diseases
10.3760/cma.j.cn115354-20230815-00062
- VernacularTitle:铜稳态与铜死亡在中枢神经系统疾病中的研究进展
- Author:
Zhipeng ZHU
1
;
Min SONG
;
Jianxun REN
;
Lirong LIANG
;
Zujue CHENG
;
Guohua MAO
;
Min CHEN
Author Information
1. 南昌大学第二附属医院神经外科，南昌 330006
- Keywords:
Copper homeostasis;
Copper death;
Central nervous system disease
- From:
Chinese Journal of Neuromedicine
2023;22(12):1277-1281
- CountryChina
- Language:Chinese
-
Abstract:
As an essential trace element in living organisms, copper is actively involved in normal physiological processes in various systems and is maintained at low level to achieve copper homeostasis. Copper homeostasis, once being disrupted, would induce cell death, and this new form of cell death is known as copper death. In recent years, copper death has been increasingly recognized as an important factor mediating the onset and progression of central nervous system (CNS) diseases. Therefore, we review the pathogenic mechanism of copper death in CNS diseases, as well as its therapeutic strategies so as to deepen the understanding of researchers.
