Recent advance in role of ubiquitin-specific protease 11 in central nervous system diseases
10.3760/cma.j.cn115354-20230307-00128
- VernacularTitle:泛素特异性蛋白酶11在中枢神经系统疾病中的作用研究进展
- Author:
Xinyan DU
1
;
Zhongzhong LI
;
Yansu GUO
Author Information
1. 首都医科大学宣武医院老年保健及疾病防治中心办公室，北京 100053
- Keywords:
Ubiquitin-specific protease 11;
Brain tumor;
Spinal cord ischemia-reperfusion injury;
Intracerebral hemorrhage;
Tauopathy
- From:
Chinese Journal of Neuromedicine
2023;22(12):1272-1276
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-specific protease 11 (USP11) is a family member of deubiquitylases (DUBs). It mediates substrates de-ubiquitination to inhibit their ubiquitin-proteasome degradation and participates in cell cycle process, DNA damage repair, cell death, autophagy, signal transduction, immune inflammatory response, cerebral cortex development, and other physiological processes. Studies show that USP11 also plays an important role in central nervous system diseases. This article starts with the structure and functions of USP11 to systematically review the mechanism of USP11 in central nervous system diseases and provide new ideas for USP11 as a therapeutic target.
