Recent advance in role of real-time quaking-induced conversion technique in α-synucleinopathies
10.3760/cma.j.cn115354-20230612-00324
- VernacularTitle:实时震荡诱导转化技术在α-突触核蛋白谱系病中的作用研究进展
- Author:
Rui ZHANG
1
;
Tingting GAN
;
Hengxu MAO
;
Xiaokang ZHANG
;
Pingyi XU
Author Information
1. 赣南医学院第一临床医学院，赣州 341000
- Keywords:
α-synucleinopathies;
α-synuclein;
Real-time quaking-induced conversion technique
- From:
Chinese Journal of Neuromedicine
2023;22(12):1267-1271
- CountryChina
- Language:Chinese
-
Abstract:
Lewy bodies formed by abnormal deposition of α-synuclein (α-syn) in neurons and glial cells are diagnostic markers of α-synucleinopathies. However, the early diagnosis of α-synucleinopathies is delayed due to the difficulty of brain biopsy at present. Because that α-syn can produce prion-like replication and spread to the periphery under pathological conditions, the ultramicro detection of pathologic α-syn in extracranial tissues by real-time quaking-induced conversion (RT-QuIC) technique can provide a basis for early diagnosis of α-synucleinopathies. In this paper, we review RT-QuIC technique in detecting α-syn seeding activity in different tissues of patients with α-synucleinopathies to summarize the potential value of RT-QuIC technique in early diagnosis or differential diagnosis of α-synucleinopathies.
