Recent advance in role of microglia in sepsis associated encephalopathy

VernacularTitle:小胶质细胞在脓毒症相关性脑病中的作用研究进展
Author: Siqi MA ¹ ; Xiaoyu YIN ; Jinchun SHEN
Author Information

1. 南京医科大学金陵临床医学院（解放军东部战区总医院）麻醉科，南京　210002
Keywords: Sepsis-associated encephalopathy; Microglia; Cell surface receptor
From: Chinese Journal of Neuromedicine 2023;22(11):1179-1182
CountryChina
Language:Chinese
Abstract: Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction caused by sepsis, characterized by altered consciousness and cognitive dysfunction. Microglia, as the main immune cells in the brain, is an important factor in SAE progression. Microglia surface receptors play important roles in SAE pathogenesis by affecting microglia activation; in addition, microglia activation is involved in SAE by exacerbating neuroinflammation, impairing the blood-brain barrier and synaptic function. In this paper, the mechanism of microglial surface receptors and microglial activation in SAE development is reviewed to provide new ideas for SAE prevention and treatment.