Recent advance in neutrophil extracellular traps in ischemic stroke

VernacularTitle:中性粒细胞胞外陷阱在缺血性脑卒中中的研究进展
Author: Wenhu LIU ¹ ; Juan BAO ; Shaobo MA ; Zhaomeng WEN ; Yuwei SHI ; Jin LIANG
Author Information

1. 甘肃中医药大学第一临床医学院，兰州　730000
Keywords: Neutrophil extracellular trap; Ischemic stroke; Perivascular space; Pathological process
From: Chinese Journal of Neuromedicine 2023;22(11):1164-1168
CountryChina
Language:Chinese
Abstract: Neutrophil extracellular traps (NETs) are compounds composed of depolymerized DNA fibers and antimicrobial peptides released by neutrophils. NETs formation not only plays a role in pathological process of non-infectious diseases such as cystic fibrosis, systemic lupus erythematosus, diabetes and cancer, but also is closely related to many central nervous system diseases. In recent years, a large number of studies have found the presence of neutrophils and NETs in perivascular space of the infarcted lesions in patients with ischemic stroke (IS) and corresponding animal models. This article provides a review on NETs formation and clearance process, characteristics of NETs changes after IS, pathological processes involved in NETs after IS, and effects of NETs on neurons, to provide some references for IS.