Correlations of hippocampal subfield volumes with cerebrospinal fluid biomarkers in patients with Alzheimer's disease
10.3760/cma.j.cn115354-20230721-00016
- VernacularTitle:阿尔茨海默病患者海马亚区体积与脑脊液生物标志物的相关性研究
- Author:
Zhengyang ZHU
1
;
Chengbing GONG
;
Ruomeng QIN
;
Wenting SONG
;
Hui ZHAO
;
Yun XU
Author Information
1. 南京中医药大学鼓楼临床医学院神经内科，南京 210008
- Keywords:
Alzheimer's disease;
Hippocampal subfield;
Cerebrospinal fluid;
Bmyloid protein;
Tau protein
- From:
Chinese Journal of Neuromedicine
2023;22(10):1023-1029
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlations of hippocampal subfield volumes with cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) patients.Methods:Forty-nine patients with cognitive impairment, including 30 AD patients and 19 non-AD patients, were recruited in Department of Neurology, Drum Tower Clinical College, Nanjing University of Chinese Medicine from May 2017 to December 2021. Concentrations of Aβ 1-42, total tau protein and phosphorylated tau protein in CSF were analyzed by enzyme-linked immunosorbent assay (ELISA). Volumes of 12 hippocampal subfields were calculated using FreeSurfer image analysis. Differences of clinical data, neuropsychological scores and CSF biomarker concentrations between the 2 groups were compared. Partial correlation was performed to analyze the correlations of volumes of hippocampal subfields with CSF biomarker concentrations. Results:AD patients had significantly lower Mini-mental State Examination (MMSE) scores and Aβ 1-42 concentration in CSF than non-AD patients ( P<0.05); AD patients had significantly lower volumes of the right hippocampal parasitulum, dentate gyrus and CA4 than non-AD group ( P<0.05); the right parasubiculum volume was negatively correlated with CSF Aβ 1-42 ( r=-0.445, P=0.023) and positively correlated with CSF P-tau ( r=0.393, P=0.047) in AD patients. Volumes of left hippocampus tail, parasubiculum, CA1, molecular layer, dentate gyrus, CA3 and CA4 were negatively correlated with CSF total tau ( P<0.05). No significant correlation was noted between hippocampal subfield volumes and CSF biomarker concentrations in non-AD patients. Conclusion:Some right hippocampal subfields in AD patients atrophy compared with those in non-AD patients with cognitive impairment; the right parasubiculum may play a compensatory role in disease process, while volumes of the left hippocampus decreased with increased CSF total tau.
