Recent advance in role of nicotinamide mononucleotide in central nervous system diseases
10.3760/cma.j.cn115354-20230210-00067
- VernacularTitle:烟酰胺单核苷酸在中枢神经系统疾病中的作用研究进展
- Author:
Chunjia ZHANG
1
;
Yan LI
;
Yan YU
;
Fan BAI
;
Yingli JING
;
Degang YANG
;
Feng GAO
;
Jianjun LI
Author Information
1. 首都医科大学康复医学院，北京 100069
- Keywords:
Nicotinamide mononucleotide;
Central nervous system disease;
Neuroprotection
- From:
Chinese Journal of Neuromedicine
2023;22(9):947-952
- CountryChina
- Language:Chinese
-
Abstract:
Nicotinamide mononucleotide (NMN) is an important precursor in conversing nicotinamide adenine dinucleotide (NAD +) in the body. By elevating NAD + level in the body, NMN enhances the hydrogen transfer function of NAD + in biological processes, promotes the synthesis of proteins and polysaccharides, improves substance transportation and regulatory efficiency, and enhances metabolic functions. Specifically, in central nervous system disease, NMN exerts neuroprotective effect through antioxidation, anti-inflammation, mitochondrial protection, and prevention of neuronal and axonal degeneration. This review focuses on the therapeutic role of NMN in common central nervous system diseases and their neuroprotective mechanisms, so as to further understand the role of NMN in central nervous system diseases, and provide references for predicting therapeutic targets and screening therapeutic drugs for central nervous system diseases.
