Recent advance in TDP-43 proteinopathy in diagnosing and treating Alzheimer's disease
10.3760/cma.j.cn115354-20221108-00807
- VernacularTitle:TDP-43病理蛋白在阿尔茨海默病诊疗中的研究进展
- Author:
Hongfu JIN
1
;
Hui SUN
;
Shenrui GUO
;
Yiyuan FENG
;
Yafu YIN
;
Hui WANG
;
Weiwei CHENG
Author Information
1. 上海交通大学医学院附属新华医院核医学科，上海 200092
- Keywords:
Alzheimer's disease;
TDP-43 proteinopathy;
Limbic-predominant age-related TDP-43 encephalopathy;
Imaging diagnosis
- From:
Chinese Journal of Neuromedicine
2023;22(9):942-946
- CountryChina
- Language:Chinese
-
Abstract:
The important role of TDP-43 proteinopathy in Alzheimer's disease (AD) has been gradually revealed. High proportion of AD patients have TDP-43 proteinopathy on their postmortem diagnosis. Patients with TDP-43 proteinopathy show more sever hippocampal atrophy and cognitive dysfunction, suggesting that TDP-43 proteinopathy can serve as an important target in AD diagnosis and treatment. Evaluation of TDP-43 proteinopathy in vivo would hold great promise in AD diagnosis, drug development and treatment. In this review, we describe the pathological characteristics of TDP-43 proteinopathy in AD, and summarize the recent progress of TDP-43 proteinopathy in the diagnosis and treatment of AD.
