Recent advance in mechanism of Hevin/SPARC in central nervous system synaptogenesis/reorganization
10.3760/cma.j.cn115354-20230223-00095
- VernacularTitle:Hevin/SPARC在中枢神经系统突触形成/重塑中的作用机制研究进展
- Author:
Yao WANG
1
;
Xingyue HAN
;
Jing XU
;
Xin CHEN
;
Sixun YU
;
Haifeng SHU
Author Information
1. 西南交通大学医学院生物医学工程研究院，成都 610031
- Keywords:
Hevin;
Secreted protein, acidic and rich in cysteine;
Synaptogenesis;
Synaptic reorganization;
Central nervous system disease
- From:
Chinese Journal of Neuromedicine
2023;22(9):937-941
- CountryChina
- Language:Chinese
-
Abstract:
Hevin is one of the extracellular matrix proteins secreted by astrocytes. Under physiological conditions, Hevin plays an important role in synaptogenesis in the central nervous system (CNS); secreted protein, acidic and rich in cysteine (SPARC) is its homologue and antagonizes the synaptogenic effects of Hevin. In pathological conditions, the expressions of Hevin and SPARC are altered, suggesting their possible roles at synaptic reorganization in various disease process, such as brain injury, Alzheimer's disease, epilepsy and brain tumors; however, the specific mechanism is not totally understood yet. So this paper reviews the mechanism of Hevin/SPARC in CNS synaptogenesis, reorganization and diseases to provide ideas for further research.
