Effect of pallidal deep brain stimulation on motor and non-motor functions in patients with Meige syndrome
10.3760/cma.j.cn115354-20230620-00346
- VernacularTitle:苍白球内侧核脑深部电刺激术对Meige综合征患者运动和非运动功能的影响
- Author:
Wentao ZHENG
1
;
Qingpei HAO
;
Yezu LIU
;
Hu DING
;
Guangyong WU
;
Zihao ZHANG
;
Ruen LIU
Author Information
1. 北京大学人民医院神经外科，北京 100044
- Keywords:
Meige syndrome;
Globus pallidus internus;
Deep brain stimulation;
Motor symptom;
Neuropsychological function
- From:
Chinese Journal of Neuromedicine
2023;22(8):801-807
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of bilateral globus pallidus internus deep brain stimulation (GPi-DBS) on motor performance, quality of life, sleep quality, neuropsychological status, and mood in patients with Meige syndrome.Methods:The clinical data of 17 patients with Meige syndrome accepted bilateral GPi-DBS in Department of Neurosurgery, People's Hospital of Peking University from May 2019 to March 2021 were retrospectively analyzed. Established and validated rating scales were used to assess the motor performance, quality of life, sleep quality, neuropsychological status, and mood at baseline, and 1 and 2 years after GPi-DBS.Results:Burke-Fahn-Marsden dystonia rating scale (BFMDRS) motor total scores decreased from 14.4±6.2 at baseline to 4.3±2.2 and 3.5±1.9 at 1 and 2 years after GPi-DBS, with significant differences ( P<0.05). BFMDRS disability total scores decreased from 6.2±4.0 at baseline to 2.8±2.0 and 2.2±1.5 at 1 and 2 years after GPi-DBS, with significant differences ( P<0.05). In 36-item Short-Form Health Survey (SF-36), the scores of physical function, role-physical, general health sub-items at 1 and 2 years after GPi-DBS were significantly higher than those at baseline ( P<0.05). No significant differences were noted in scores of sleep quality, neuropsychological function, or mood scales at 1 and 2 years after GPi-DBS compared with those at baseline ( P>0.05). Conclusion:Bilateral GPi-DBS is effective and safe in Meige syndrome, which can improve dystonic symptom and quality of life without adverse effects on sleep quality, neuropsychological function, or emotional status.
