Effect of rt-PA intravenous thrombolysis on thrombi after mechanical thrombectomy in patients with acute ischemic stroke
10.3760/cma.j.cn115354-20230523-00291
- VernacularTitle:rt-PA静脉溶栓对急性缺血性脑卒中机械取栓后血栓的影响
- Author:
Liao WU
1
;
Xiaoyu NI
;
Xiaotian ZHANG
;
Peng ZUO
;
Shikun CAI
;
Bo SUN
;
Guihua NI
Author Information
1. 南京医科大学附属淮安第一医院神经内科，淮安 223300
- Keywords:
Ischemic stroke;
Thrombus;
Intravenous thrombolysis;
Mechanical thrombectomy
- From:
Chinese Journal of Neuromedicine
2023;22(8):780-785
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) on sizes and components of thrombi in patients with acute ischemic stroke (AIS) after mechanical thrombectomy (MT).Methods:Ninety-eight AIS patients accepted MT in Department of Neurology, Huaian First Hospital Affiliated to Nanjing Medical University from June 2018 to June 2022 were enrolled; they were divided into bridging therapy group and direct thrombectomy group according to the treatments. Baseline data, prognoses and thrombus features between the 2 groups were compared.Results:No significant differences were observed between the 2 groups in terms of age, gender, previous medical history, baseline scores, sites and types of vascular occlusion, TOAST causative classifications, time frame, MT frequencies and techniques, successful recanalization, or prognoses 90 d after MT ( P>0.05). Compared with the direct thrombectomy group, the bridging therapy group had significantly reduced thrombus area (37[22, 78] mm 2vs. 27[14, 62] mm 2) and areas of major pathological components [red blood cells: 16.1([9.0, 37.4] mm 2vs. 11.8[6.1, 22.1] mm 2, fibrin/platelets: 19.5[9.5, 26.4] mm 2vs. 10.7[5.0, 22.8] mm 2, white blood cells: 4.0[2.2, 8.0] mm 2vs. 2.4[1.4, 5.7] mm 2, P<0.05); however, no significant differences in proportions of areas of major pathological components were noted between the 2 groups of patients ( P>0.05). Conclusion:The rt-PA intravenous thrombolysis can significantly reduce the thrombi volume and decrease the contents of major thrombus components in AIS patients after MT, but not change the proportions of major pathological components in thrombi.
