Recent advance in animal model of hydrocephalus
10.3760/cma.j.cn115354-20230103-00004
- VernacularTitle:脑积水动物模型的研究进展
- Author:
Xuehai DENG
1
;
Hangyang LI
;
Jianlin DING
;
Xingyuan HANG
;
Xinlong CHEN
;
Long ZHAO
Author Information
1. 川北医学院附属医院神经外科研究室，南充 637000
- Keywords:
Congenital hydrocephalus;
Secondary hydrocephalus;
Animal model
- From:
Chinese Journal of Neuromedicine
2023;22(6):636-641
- CountryChina
- Language:Chinese
-
Abstract:
Animal model of hydrocephalus is an important object to study the mechanism, pathological characteristics, and treatment of hydrocephalus. A stable and controllable animal model in accordance with clinical development of hydrocephalus can help to develope hydrocephalus related basic research and clinical translational application. According to the study purpose and genetic and physiological characteristics of experimental animals, a variety of animals have been used to establish different types of hydrocephalus animal models. The methods for congenital hydrocephalus models include gene edition and metabolic induction, while secondary hydrocephalus models can be induced by blocking the circulation of cerebrospinal fluid and interfering cerebrospinal fluid absorption. The hydrocephalus models constructed by different methods are also different in progression, neurofunctional changes, and histopathological characteristics. This paper reviews the construction methods and pathological characteristics of various hydrocephalus models in order to provide references for selection of animal models for hydrocephalus-related research.
