Recent advance in silencing mechanism of corticotroph tumors
10.3760/cma.j.cn115354-20221027-00748
- VernacularTitle:促肾上腺皮质激素细胞肿瘤生化静默机制研究进展
- Author:
Yingxuan SUN
1
;
Chuzhong LI
;
Yazhuo ZHANG
Author Information
1. 首都医科大学，北京市神经外科研究所，北京 100070
- Keywords:
Corticotroph tumor;
Biochemical silence;
Pro-opiomelanocortin;
Adrenocorticotrophic hormone
- From:
Chinese Journal of Neuromedicine
2023;22(6):623-626
- CountryChina
- Language:Chinese
-
Abstract:
Corticotroph tumors (CTs) are classified into functional CTs and silent CTs (SCTs)according to presence or absence of Cushing's disease manifestations. The pathological manifestations of functional CTs and SCTs are consistent, and both adrenocorticotrophic hormone (ACTH) and T-box transcription factor TBX19 expressions are seen by immunohistochemistry. SCTs have normal peripheral blood ACTH levels, without Cushing's disease manifestations; and SCTs exhibit invasive growth with high recurrence rate. Some studies have suggested that the biochemical silencing mechanism of SCTs involves pro-opiomelanocortin ( POMC, ACTH precursor) gene expression and ACTH secretion. In this paper, the biochemical silencing mechanism of SCTs will be reviewed from aspects of physiological synthesis and regulation of ACTH in normal adenohypophysial cells, and transcription, post-transcriptional regulation, and post-translational regulation of POMC gene, and ACTH abnormal secretion in SCTs.
