Diffusion tensor imaging in patients with chronic migraine: an analysis with atlas-based analysis and tract-based spatial statistics
10.3760/cma.j.cn115354-20230202-00051
- VernacularTitle:慢性偏头痛患者脑白质弥散张量成像ABA及TBSS分析
- Author:
Xiaolin HOU
1
;
Dongdong YANG
;
Shanyu LIU
;
Yuan ZHOU
Author Information
1. 成都中医药大学附属医院神经外科，成都 610072
- Keywords:
Chronic migraine;
Diffusion tensor imaging;
Atlas-based analysis;
Tract-based spatial statistics
- From:
Chinese Journal of Neuromedicine
2023;22(6):541-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the structural damage of cerebral white matter in patients with chronic migraine (CM) using magnetic resonance diffusion tensor imaging (DTI), and analyze its correlation with clinical data.Methods:Sixty CM patients, enrolled from Outpatient of Departments of Neurosurgery and Neurology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from September 2020 to December 2022, were chosen; and from October 2020 to June 2022, 60 healthy controls matched with age and gender were recruited socially. All subjects accepted whole brain DTI. DTI data were automatically processed by PANDA and FSL softwares, differences of whole brain DTI data between CM patients and healthy controls were compared by atlas-based analysis (ABA) and tract-based spatial statistics (TBSS), and correlations of clinical features with ABA results were analyzed by Pearson correlation in CM patients.Results:In ABA, compared with the healthy control group, the CM group had significantly decreased FA values in the bilateral cerebral peduncles, left inferior cerebellar peduncles, right superior cerebellar peduncles, bilateral medial thalamic tracts, bilateral tapetum (the inner sagittal layer of the corpus callosum), bilateral hook bundles, and right posterior limb of the internal capsule ( P<0.05); compared with the healthy control group, the CM group had significantly increased mean diffusivity (MD) in the right cingulate gyrus and posterior part of the internal lenticular nucleus, statistically decreased axial diffusivity (AD) in the bilateral cerebral peduncles, bilateral medial thalamic tracts, and right cingulate gyrus ( P<0.05); compared with the healthy control group, the CM group had significantly increased radial diffusivity (RD) in the left tapetum, left inferior cerebellar peduncles, and cerebral peduncles ( P<0.05). In TBSS, no differences in FA, MD, RD and AD in the white matter fiber skeleton were noted between the 2 groups ( P>0.05). In CM patients, visual analogue scale (VAS) scores were negatively correlated with FA in the left subiculum, left medial colliculus and right cerebral peduncle, AD in the right cerebral peduncle, and RD in the left tapetum ( P<0.05); disease duration was negatively correlated with FA in the left subiculum peduncle and positively correlated with RD in the left subiculum peduncle ( P<0.05). Conclusions:Notwithstanding the structural damage of cerebral white matter in CM patients, the white matter fiber skeleton remains unaltered from normal subjects, without pathological damage of the fiber skeleton. Structural changes in the brainstem, cerebellum and corpus callosum are associated with VAS scores and disease duration, and may be important factors for CM pathogenesis.
