Cluster management in secondary hydrocephalus
10.3760/cma.j.cn115354-20221227-00937
- VernacularTitle:集束化管理在继发性脑积水治疗中的应用价值分析
- Author:
Jun LIU
1
;
Xianjian HUANG
;
Jie GAO
;
Xiaosong SHA
;
Jiehua ZHANG
;
Dongliang ZHU
;
Chuwei WU
;
Gaojian SU
Author Information
1. 深圳市第二人民医院 深圳大学第一附属医院神经外科，深圳 518035
- Keywords:
Secondary hydrocephalus;
Ventriculoperitoneal shunt;
Cluster management;
DNA metagenomic next generation sequencing;
Ventriculoscopy
- From:
Chinese Journal of Neuromedicine
2023;22(5):507-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of cluster management in secondary hydrocephalus.Methods:Seventy-seven patients with secondary hydrocephalus admitted to Department of Neurosurgery, Shenzhen Second People's Hospital from January 2016 to June 2021 were chosen; they were divided into traditional management group ( n=30) and cluster management group ( n=47) according to different management methods. Patients in traditional management group accepted craniocerebral CT and 3 consecutive times of cerebrospinal fluid tests, and normal results were achieved and then ventriculoperitoneal shunt (VPS) was performed. In patients from the cluster management group, on the basis of management treatment, cranial plain and enhanced MRI and DNA metagenomic next generation sequencing of cerebrospinal fluid were performed before surgery, and rapid test of cerebrospinal fluid and ventriculoscope observation were performed during surgery; after exclusion of intracranial infection, VPS was performed. The differences of shunt failure rate were compared between the two groups and the positive rates of intracranial infection detected by above 4 methods were compared in the cluster management group. Results:There was significant difference in shunt failure rate between the cluster management group and traditional management group (2.1% vs. 20.0%, P<0.05). The positive rates of intracranial infection by DNA metagenomics (61.7%) and ventriculoscopy (68.1%) were significantly higher than those by preoperative cranial plain and enhanced MRI (14.9%) and rapid test of cerebrospinal fluid (6.4%, P<0.05). Conclusion:Cluster management can effectively decrease the VPS failure rate in secondary hydrocephalus; DNA metagenomics and ventriculoscopy have high efficiency in detecting intracranial infection.
