Chemoprevention of Gastric Cancer: Statins.
10.7704/kjhugr.2017.17.4.175
- Author:
Sang Hyeon CHOI
1
;
Gwang Ho BAIK
Author Information
1. Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea. baikgh@hallym.or.kr
- Publication Type:Review
- Keywords:
Chemoprevention;
Hydroxymethylglutaryl-CoA reductase inhibitors;
Stomach neoplasms
- MeSH:
Chemoprevention*;
Cholesterol;
Coenzyme A;
Hydroxymethylglutaryl-CoA Reductase Inhibitors*;
Mortality;
Oxidoreductases;
Stomach Neoplasms*
- From:The Korean Journal of Helicobacter and Upper Gastrointestinal Research
2017;17(4):175-178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, the enzyme involved in the rate-limiting step in cholesterol synthesis. Several studies have shown that statins have potential protective effects against gastric cancer; however, other studies have reported contradictory results. Therefore, further studies are needed to clarify the role of statins in the chemoprevention of gastric cancer.
