Changes in structural and functional connectivity of different hippocampal subregions in courses of Alzheimer's disease
10.3760/cma.j.cn115354-20230317-00159
- VernacularTitle:不同海马亚区在阿尔茨海默病病程中的结构和功能连接变化
- Author:
Lianghui NI
1
;
Yuxia LI
;
Ying HAN
Author Information
1. 首都医科大学宣武医院神经内科，北京 100053
- Keywords:
Alzheimer's disease;
Hippocampal subregion;
Structural connectivity;
Functional connectivity
- From:
Chinese Journal of Neuromedicine
2023;22(5):453-461
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes in structural and functional connectivity of different hippocampal subregions in courses of Alzheimer's disease (AD).Methods:One hundred and seventeen subjects from Sino Longitudinal Study on Cognitive Decline (SILCODE) were chosen; their cognitive functions were assessed using neuropsychological tests, and brain beta-amyloid (Aβ) levels were measured using PET-MRI. These patients were divided into group of normal cognitive function and negative Aβ ( n=68), group of normal cognitive function and positive Aβ ( n=29), and group of cognitive impairment and positive Aβ ( n=20); neuropsychological characteristics and changes in volume, structural connectivity and functional connectivity of hippocampal subareas were compared among the 3 groups. Results:Compared with group of normal cognitive function and negative Aβ and group of normal cognitive function and positive Aβ, group of cognitive impairment and positive Aβ had significantly decreased scores of Mini-mental State Examination (MMSE), Montreal Cognitive Assessment-Basic Version (MoCA-B), Auditory Verbal Learning Test (AVLT)-Short-term Delayed Recall (SR), AVLT-Long-term Delayed Recall (LR), Animal Fluency Test (AFT) and Boston Naming Test (BNT), and statistically increased Shape Trails Test B (STT-B) scores ( P<0.05). Compared with group of normal cognitive function and negative Aβ and group of normal cognitive function and positive Aβ, group of cognitive impairment and positive Aβ had significantly decreased volumes of the left and right hippocampal CA1, CA2, CA3, dentate gyrus (DG), entolorhinal cortex (EC) and inferior support area (Sub, P<0.05). Compared with group of normal cognitive function and negative Aβ, group of normal cognitive function and positive Aβ had increased or decreased structural connectivity, and almost all increased functional connectivity of each hippocampal subregion; compared with group of normal cognitive function and negative Aβ, group of cognitive impairment and positive Aβ had almost all increased structural connectivity, and almost all decreased functional connectivity of each hippocampal subregion. Conclusion:Changes in gray matter volume and structural and functional connectivity in various hippocampal subregions are different in courses of AD.
