Recent advance in histone deacetylation in epilepsy pathogenesis and treatment
10.3760/cma.j.cn115354-20221012-00708
- VernacularTitle:组蛋白去乙酰化在癫痫发病及治疗中的研究新进展
- Author:
Jiaxin ZHAO
1
;
Junlin SHI
;
Guohe TAN
Author Information
1. 广西脑科学研究重点实验室，广西医科大学神经科学研究所，广西医科大学基础医学院人体解剖学教研室，南宁 530021
- Keywords:
Epilepsy;
Histone deacetylation;
Histone deacetylase inhibitor
- From:
Chinese Journal of Neuromedicine
2023;22(4):422-428
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is a complex neurological disease and its pathogenesis has not yet been clear. More and more evidence shows that epilepsy is closely related to epigenetic mechanisms such as histone deacetylation. Histone deacetylase inhibitors, a kind of epilepsy targeting drug potentially, are involved in the protection of neurogenesis and the regulation of a variety of neural signal cascade reactions. This article reviews the research progress of histone deacetylation in the pathogenesis of epilepsy and application prospect of histone deacetylase inhibitors in treating epilepsy.
