Recent advance in role of cyclic GMP-AMP synthase-stimulator of interferon gene signal pathway in brain tumors
10.3760/cma.j.cn115354-20221008-00688
- VernacularTitle:cGAS-STING信号通路在脑肿瘤中的研究进展
- Author:
Min SONG
1
;
Zhipeng ZHU
;
Guohua MAO
;
Zijie ZHOU
;
Min CHEN
Author Information
1. 南昌大学第二附属医院神经外科，南昌 330006
- Keywords:
Cyclic GMP-AMP synthase-stimulator of interferon gene signaling pathway;
Brain tumor;
Type I interferon;
Tumor immunotherapy
- From:
Chinese Journal of Neuromedicine
2023;22(4):405-409
- CountryChina
- Language:Chinese
-
Abstract:
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING) signal pathway is a classical pathway of STING activation, and in recent years, its role in stimulating innate immunity has gradually attracted wide attention. Besides, cGAS can recognize and combine endogenous or exogenous DNA, then catalyze ATP and GTP to synthesize cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), subsequently activate STING signal to promote type I interferon and inflammatory factors, finally induce natural and adaptive immunity. Existing studies have indicated that cGAS-STING signal pathway plays an important role in infections, inflammations and tumors, especially in high-grade gliomas with poor clinical treatment efficacy. Here, we briefly summarize the cGAS-STING signal pathway and its mechanism in brain tumors to provide new ideas for exploring therapeutic targets and drugs for brain tumors.
