Recent advance in role of adenovirus E1A binding protein p300 in glioblastoma

VernacularTitle:腺病毒早期区域1A蛋白结合p300蛋白在胶质母细胞瘤中的相关研究进展
Author: Dongying ZHENG ¹ ; Jia WU ; Yuntao LU ; Yuping PENG
Author Information

1. 南方医科大学南方医院神经外科，广州　510515
Keywords: Glioblastoma; Adenovirus E1A binding protein p300; Transcriptional coactivator; Acetylation
From: Chinese Journal of Neuromedicine 2023;22(4):399-404
CountryChina
Language:Chinese
Abstract: Glioblastoma (GBM), characterized by rapid progression, easy recurrence and treatment resistance, is the most aggressive and lethal tumor of the central nervous system. Adenovirus E1A binding protein p300 (p300) serves rich functions as transcriptional coactivator and lysine acetyltransferase. Studies have shown that p300 plays an important role in the occurrence, proliferation, invasion and resistance to chemoradiotherapy of GBM. This paper reviews the structure and function of p300, and systematically expounds its various ways participating in GBM development and its translational perspectives, so as to provide references for GBM study.