Recent advance in relations of programmed cell death-1/programmed cell death-ligands-1 pathway with multiple sclerosis
10.3760/cma.j.cn115354-20220615-00423
- VernacularTitle:PD-1/PD-L1通路与多发性硬化关系的研究进展
- Author:
Xiangfei MENG
1
;
Xianghui MENG
;
Wenwei SUN
Author Information
1. 临沂市中医医院脑病科，临沂 276003
- Keywords:
Multiple sclerosis;
Experimental autoimmune encephalomyelitis;
Programmed cell death-1;
Programmed cell death-ligands-1;
Lymphocyte
- From:
Chinese Journal of Neuromedicine
2023;22(3):311-317
- CountryChina
- Language:Chinese
-
Abstract:
Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination, axonal injury, and neuronal loss in central nervous system. Experimental autoimmune encephalomyelitis (EAE) animal model is widely used in MS. Accumulating evidences indicate that the programmed cell death-1/programmed cell death-ligands-1 (PD-1/PD-L1) pathway participates in pathogenesis of autoimmune diseases. The authors comprehensively review the roles of PD-1/PD-L1 pathway in pathogenesis of MS and EAE animal model, and discuss the potential of this pathway as a new therapeutic target for MS, to provide reference for immunotherapy research of MS.
