Recent advance in role and treatment of brain-derived neurotrophic factor imbalance in neurodegenerative diseases

VernacularTitle:脑源性神经营养因子失平衡在神经退行性疾病中的作用及治疗应用研究进展
Author: Feng LIU ¹ ; Limin LIU ; Xiaoyu WU ; Weihao XING ; Jing XIONG
Author Information

1. 昆明医科大学第二附属医院神经内科，昆明　650106
Keywords: Mature brain-derived neurotrophic factor; Brain-derived neurotrophic factor precursor; Alzheimer's disease; Parkinson's disease
From: Chinese Journal of Neuromedicine 2023;22(3):295-300
CountryChina
Language:Chinese
Abstract: The two forms of brain-derived neurotrophic factor (BDNF), mature BDNF (mBDNF) and BDNF precursor (proBDNF), bind to corresponding receptors and mediate a series of biological signals, which play important roles in proliferation, survival and apoptosis. More and more studies have focused on the role of unbalanced transformation from proBDNF to mBDNF in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as their potential as biomarkers and treatment targets. This article reviews the mechanism and therapeutic application of BDNF and proBDNF/mBDNF imbalance in the above-mentioned neurodegenerative diseases to provide new perspective and approach for the pathogenesis, early diagnosis and treatment of neurodegenerative diseases such as AD and PD.