Role of microglia-astrocyte crosstalk in central nervous system demyelinating diseases
10.3760/cma.j.cn115354-20220830-00593
- VernacularTitle:小胶质细胞-星形胶质细胞串扰在中枢神经系统脱髓鞘疾病中的作用
- Author:
Jinyun MA
1
;
Xiaodong CHENG
Author Information
1. 上海中医药大学附属岳阳中西医结合医院临床免疫研究所，上海 200437
- Keywords:
Microglia-astrocyte crosstalk;
Neuroinflammation;
Neuroprotection;
Demyelinating disease;
Remyelination
- From:
Chinese Journal of Neuromedicine
2023;22(3):289-294
- CountryChina
- Language:Chinese
-
Abstract:
Microglia-astrocyte (MG-AS) crosstalk refers to the molecular conversation, mutual communication and interaction between MG and AS, thus affecting the process of brain development, function and diseases. MG determines the neurotoxic and neuroprotective phenotype of AS and regulates the innate immune function of AS; on the other hand, AS affects MG activation state, and regulates migration and phagocytosis of MG. MG-AS crosstalk plays roles in regulating neuroinflammation, neurotoxicity, neuroprotection, demyelination and myelin regeneration in central nervous system demyelinating diseases; meanwhile, multiple signaling pathways and molecules regulate MG-AS crosstalk in turn, which further affects the development of demyelinating diseases. The author summarizes and discusses the recent advance in this field at home and abroad.
