Frontiers of cellular replacement therapy for cerebral infarction
10.3760/cma.j.cn115354-20220810-00555
- VernacularTitle:脑梗死后神经细胞替代治疗的前沿进展
- Author:
Siqi GONG
1
;
Han SHAO
;
Anqi TANG
;
Xiaoyan YANG
;
Xiuying CAI
;
Juehua ZHU
Author Information
1. 苏州大学附属第一医院神经内科，苏州 215006
- Keywords:
Cerebral infarction;
Cellular replacement;
Stem cell;
Neurogenesis
- From:
Chinese Journal of Neuromedicine
2023;22(1):72-76
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral infarction, with high incidence, high mortality, high disability and high recurrence rates, can impose a serious burden on families and society. After cerebral infarction occurrence, neurons, as the fundamental structures of the central nervous system, are unable to renew or multiply after death; hence, full recovery from neurological impairments following cerebral infarction is challenging. With stem cell and genetic recombination advancements, cellular replacement therapy after cerebral infarction progresses, which helps clinical transformation and application. In this paper, the basic researches of cellular replacement therapy after cerebral infarction are reviewed from 3 aspects: endogenous nerve regeneration, exogenous stem cell transplantation, and in situ somatic cell trans-differentiation into neurons, in order to provide references for cerebral infarction treatment
