Recent advance in protein homeostasis mediated by liquid-liquid phase separation in neurodegenerative diseases
10.3760/cma.j.cn115354-20220728-00527
- VernacularTitle:液-液相分离介导的蛋白质稳态调控在神经退行性疾病中的研究进展
- Author:
Yiming ZHOU
1
;
Minhui XU
;
Yan SU
;
Tianjiao XIA
;
Xiaoping GU
Author Information
1. 南京大学医学院附属鼓楼医院麻醉科，南京 210008
- Keywords:
Neurodegenerative disease;
Liquid-liquid phase separation;
Protein homeostasis
- From:
Chinese Journal of Neuromedicine
2022;21(12):1281-1285
- CountryChina
- Language:Chinese
-
Abstract:
Numerous studies have suggested that liquid-liquid phase separation (LLPS) may be involved in occurrence and progression of neurodegenerative diseases through mediating immune inflammation, transcriptional regulation, protein homeostasis, genomic stability, and oxidative stress, and regulation of LLPS-mediated protein homeostasis has attracted particular attention. Therefore, this paper reviews the research progress of mechanism of protein homeostasis regulation in neurodegenerative diseases in recent years, and discusses the prospect of LLPS related research.
