Clinical characteristics of autoimmune glial fibrillary acidic protein astrocytopathy
10.3760/cma.j.cn115354-20220513-00331
- VernacularTitle:自身免疫性胶质纤维酸性蛋白星形胶质细胞病临床特征分析
- Author:
Bei LI
1
;
Qishan ZHANG
;
Manqian LIAO
;
Yan HE
;
Linli HE
Author Information
1. 南华大学附属郴州医院 郴州市第一人民医院神经内科，郴州 423000
- Keywords:
Autoimmune encephalitis;
Glial fibrillary acidic protein astrocytopathy;
Clinical feature
- From:
Chinese Journal of Neuromedicine
2022;21(12):1245-1249
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical features of autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A).Methods:A retrospective analysis was performed. Data of 14 patients with GFAP-A, admitted to Department of Neurology, Chenzhou First People's Hospital from December 1, 2020 to May 1, 2022, were collected.Results:The mean age of these 14 patients was (46±31) years, and the male patients were more than female ones (10∶4). All patients had acute onset, and the main clinical symptoms included dizziness and headache ( n=10), fever ( n=8), urination and defecation function disturbance ( n=5), mental and behavioral abnormality ( n=4), limb weakness ( n=4), and tremor ( n=3). No tumors were found; 8 patients were with hyponatremia. Twelve patients responded well to hormone and/or immunosuppressive therapy; 2 patients refused corticosteroid and/or immunosuppressive therapy for personal reasons, and their condition did not improve at discharge. Conclusion:In these GFAP-A patients, relatively heterogeneous clinical manifestations are noted; many are complicated with hyponatremia, and some have clinical manifestations similar to nervous system infectious diseases; the prognosis is good after immunotherapy.
