Dynamic observation of degradation property of novel magnesium alloy stents in Bama mini-pig models of carotid artery stenosis by high-resolution C-arm CT: a feasibility study
10.3760/cma.j.cn115354-20220821-00575
- VernacularTitle:高分辨C臂CT对镁合金支架治疗巴马小型猪颈动脉狭窄体内降解情况动态观察可行性探讨
- Author:
Tengfei LI
1
;
Sun YU
;
Chengcheng SHI
;
Shuhai LONG
;
Ji MA
;
Zhen LI
;
Jianzhuang REN
;
Xinwei HAN
Author Information
1. 郑州大学第一附属医院放射介入科，郑州大学介入治疗研究所，郑州 450052
- Keywords:
Atherosclerotic stenosis;
Animal model;
Carotid artery stenosis;
Magnesium alloy stent
- From:
Chinese Journal of Neuromedicine
2022;21(12):1189-1194
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the degradation property of novel magnesium alloy stents in Bama mini-pig models of carotid artery stenosis, and evaluate the feasibility of observing their dynamic and continuous process by high-resolution C-arm CT.Methods:Twelve Bama mini-pigs were selected; carotid artery stenosis models were established by large balloon over-dilation and high-fat and high-salt diet in Bama pigs; 24 weeks after that, self-made braided degradable magnesium alloy stents were inserted into the carotid artery stenosis models (confirmed by DSA) by balloon dilation. Degrees of stent patency and in-stent restenosis were examined by DSA immediately after procedure and on the 30 th, 60 th and 90 th d of procedure. Four experimental pigs were sacrificed on the 30 th, 60 th and 90 th d of procedure, respectively; the degradation property of the novel magnesium alloy stents was observed according to results of high-resolution C-arm CT in the inserted-stent areas and staining results of specimens in the stenosis areas, and stent imaging features during degradation were summarized. Results:Twelve Bama mini-pig models of carotid artery stenosis were established and 12 magnesium alloy stents were successfully inserted with a technical success rate of 100%. Both immediate postoperative and follow-up angiography showed patency of the vascular lumens without obvious in-stent restenosis. High-resolution C-arm CT and pathological examination showed homogeneous stent lumens and clear delineation of the stent meshes, with slightly degraded stent on the 30 th d of procedure; the stent lumen was blurred and some magnesium alloy wires were fractured with developed degradation of the stent on the 60 th d of procedure; and the stent meshes and stent strut could not be visualized due to severe degradation of the stent on the 90 th d of procedure. Conclusion:Magnesium alloy degradable stent is almost completely degraded within 90 th d of procedure in Bama mini-pig models of carotid artery stenosis, and high-resolution C-arm CT can be used to dynamically monitor the degradation of the stent in vivo.
