Role of microglia lipid metabolism in Alzheimer's disease

VernacularTitle:小胶质细胞脂质代谢在阿尔茨海默病中的作用
Author: Minhui XU ¹ ; Yiming ZHOU ; Yan SU ; Linhao JIANG ; Jiyan XU ; Tianjiao XIA
Author Information

1. 南京大学医学院，南京　210008
Keywords: Microglia; Alzheimer's disease; Lipid metabolism
From: Chinese Journal of Neuromedicine 2022;21(11):1168-1172
CountryChina
Language:Chinese
Abstract: Microglia (MG) are resident immune cells in the central nervous system (CNS) and the first defense line of CNS damage. The maintenance of MG function requires abundant energy, and lipid can serve as an energy source for the brain when glucose utilization is limited, and lipid can also function as signaling molecule. Alzheimer's disease (AD) is the most common neurodegenerative disease, and MG lipid metabolism plays an important role in the development of this disease. Drugs targeting lipid metabolism provide a new direction for AD treatment. This review starts with the specific mechanism of lipid metabolism in MG, and briefly introduces the effect of lipid metabolism on MG function and its role in AD.