Evaluation of brain glymphatic system function in patients with multiple sclerosis based on diffusion tensor imaging
10.3760/cma.j.cn115354-20220803-00544
- VernacularTitle:基于弥散张量成像技术评估多发性硬化患者大脑类淋巴系统功能的研究
- Author:
Lin WU
1
;
Zhi ZHANG
;
Xiao LIANG
;
Yanyan ZHU
;
Honghan GONG
;
Fuqing ZHOU
Author Information
1. 南昌大学第一附属医院影像科，江西省医学影像研究所，南昌 330006
- Keywords:
Multiple sclerosis;
Glymphatic system;
Diffusion tensor imaging
- From:
Chinese Journal of Neuromedicine
2022;21(11):1133-1137
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of glymphatic system function at relapse and remission phases in patients with relapsing remitting multiple sclerosis (RRMS) and their relations with clinical parameters.Methods:Sixteen patients with RRMS at relapsing phase and 25 patients with RRMS at remitting phase, admitted to Department of Neurology, First Affiliated Hospital of Nanchang University from September 2012 to December 2020, were enrolled; and 29 normal controls were recruited at the same period in Physical Examination Center the same hospital. The diffusion tensor imaging data were analyzed retrospectively, and the along perivascular space (ALPS) index was calculated. The differences in clinical data and ALPS index among the 3 groups were compared, and the correlations between ALPS index and clinical parameters in RRMS patients were analyzed.Results:The scores of expanded disability status scale (EDSS) and modified fatigue impact scale (MFIS) in patients at relapsing phase were significantly higher than those in patients at remitting phase ( P<0.05). The ALPS index in bilateral cerebral hemispheres in the control group was significantly higher than that in RRMS patients at relapse and remission phases ( P<0.05). In patients with RRMS at relapse phase, the ALPS index in the left cerebral hemisphere was negatively correlated with disease duration and EDSS scores ( r=-0.536, P=0.032; r=-0.573, P=0.020). Conclusion:Patients with RRMS have glymphatic system dysfunction; this dysfunction may be the potential pathological basis of clinical dysfunction in patients with RRMS at relapsing phase.
