Recent adanvces in pathogenesis and immunological sequential therapy of neuromyelitis optica spectrum disorder

VernacularTitle:视神经脊髓炎谱系病的发病机制及免疫序贯治疗的研究进展
Author: Yuqing WU ¹ ; Liuyu LIN ; Hailun HANG ; Jie LU
Author Information

1. 南京医科大学附属脑科医院神经内科，南京　210029
Keywords: Neuromyelitis optica spectrum disorder; Aquaporin-4 antibody; Pathogenesis; Sequential therapy
From: Chinese Journal of Neuromedicine 2022;21(10):1067-1072
CountryChina
Language:Chinese
Abstract: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the central nervous system. Its pathogenesis is complex and mainly related to aquaporin 4 antibody. NMOSD typically follows a relapsing course leading to progressive aggravation of neurological deficits, making prevention of relapse being the key to NMOSD treatment. In addition to traditional non-specific immunosuppressants, new targeted drugs have gradually shown unique advantages in sequential treatment of NMOSD due to their significant efficacy and fewer adverse reactions. This article summarizes and reviews the pathogenesis of NMOSD and the safety and efficacy of immunosequential therapy drugs.