Recent advance in mechanism of ATP-binding cassette transporter in Alzheimer's disease
10.3760/cma.j.cn115354-20220417-00239
- VernacularTitle:ABC转运蛋白在阿尔茨海默病中的研究进展
- Author:
Jian ZHANG
1
;
Huibo GUAN
;
Miao YU
;
Quan LI
;
Yanyan ZHOU
Author Information
1. 黑龙江中医药大学基础医学院，哈尔滨 150040
- Keywords:
Adenosine triphosphate binding cassette transporter;
Alzheimer's disease;
Beta-amyloid
- From:
Chinese Journal of Neuromedicine
2022;21(10):1055-1059
- CountryChina
- Language:Chinese
-
Abstract:
ATP-binding cassette (ABC) transporters are the largest transporter families in human bodies; they are widely distributed and have complex functions. ABC transporters can mediate the translocation of various substrates on the cell membrane. This paper summarizes the structure, classification, function and action mechanism of ABC transporters and the research progress of ABC transporters in AD in recent years, and discusses the future research direction for preventing and treating AD in this field to provide new ideas and references for the prevention and treatment of AD.
