Influences of times of venous thromboembolism drug prophylaxis in deep vein thrombosis formation in patients with severe craniocerebral injury after surgical treatment
10.3760/cma.j.cn115354-20220712-00487
- VernacularTitle:重型颅脑损伤患者术后VTE药物预防时间对下肢深静脉血栓形成的影响
- Author:
Zhongxin YANG
1
;
Haibo LIU
;
Tianquan ZHAO
;
Kai YU
;
Lie ZHANG
;
Xiaoying CAO
;
Yinjun FAN
;
Xun XIA
Author Information
1. 成都医学院临床医学院、第一附属医院神经外科，成都 610500
- Keywords:
Severe craniocerebral injury;
Early period of postsurgery;
Venous thromboembolism drug prophylaxis;
Deep vein thrombosis
- From:
Chinese Journal of Neuromedicine
2022;21(10):1026-1029
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influences of times of venous thromboembolism (VTE) drug prophylaxis in formation of deep vein thrombosis (DVT) in patients with severe craniocerebral injury after surgical treatment.Methods:Ninety patients with severe craniocerebral injury, admitted to our hospital from February 2021 to December 2021, were chosen in our study; they were divided into early group ( n=47, less than 48 h from the time of admission) and late group ( n=43, more than 48 h from the time of admission) according to the times of initiation for VTE drug prophylaxis (low molecular weight heparin calcium injection [LMWH] 100 IU/Kg was injected subcutaneously once a d). One week after injection, the DVT formation in the lower limbs, intracranial rebleeding, gastrointestinal bleeding and death were compared in the two groups. Results:The times of initiation for drug prophylaxis in the early group and late group were (28.91±4.50) h and (71.56±8.89) h. The DVT formation in the early group was significantly lower than that in the late group (12.8% vs. 34.9%, P<0.05). There was no difference in the incidence of intracranial rebleeding, mortality or gastrointestinal bleeding between the two groups ( P>0.05). Conclusion:Early initiation of VTE drug prophylaxis can significantly reduce the incidence of DVT in patients with severe craniocerebral injury after surgical treatment, enjoying high safety.
