Role of coping styles in development of post-traumatic stress disorder in patients lost their only child: a brain structure study
10.3760/cma.j.cn115354-20220227-00101
- VernacularTitle:应对方式在失独所致创伤后应激障碍发生发展中作用的脑结构研究
- Author:
Huanhuan DAI
1
;
Yifeng LUO
;
Rongfeng QI
;
Jiyuan GE
;
Bo LIU
;
Qingyue LAN
;
Li ZHANG
;
Feng CHEN
;
Zhihong CAO
;
Lingjiang LI
;
Guangming LU
Author Information
1. 江苏大学附属宜兴医院放射科，无锡 214200
- Keywords:
Coping style;
Losing one's only child;
Post-traumatic stress disorder;
Voxel based morphometry;
Medicating effect
- From:
Chinese Journal of Neuromedicine
2022;21(10):989-995
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of coping style on the gray matter volume in patients with post-traumatic stress disorder (PTSD) who lost their only child, and the mediating role of gray matter volume in evaluating the influence of coping style in clinical symptoms of these parents.Methods:A total of 57 parents with PTSD (PTSD group) and 162 parents without PTSD (non-PTSD group) who lost their only child from September 2016 to March 2017 were enrolled from Jiangsu Province, China. Brain MRI data at resting state were collected. Voxel-based multiple regression analysis was performed to confirm the brain areas in which coping style main effect, diagnosis main effect and their interaction had significant influences in gray matter volumes. Correlations among gray matter volume of brain areas related to coping style, coping style scale scores, and clinician-administered PTSD scale (CAPS) scores were analyzed. Structural equation modeling was used to analyze the mediating role of gray matter volume in the influence of coping style in clinical symptoms of parents lost their only child.Results:(1) The coping style main effect did not significantly influence the gray matter volume in all subjects, and the diagnosis main effect had significant influence in gray matter volume in the right lingual gyrus; their interaction had significant influence in gray matter volume in the right peritalar fissure cortex and lingual gyrus. The positive coping style in the PTSD group had significant influence in the gray matter volumes of the right peritalar fissure cortex and lingual gyrus. (2) In the PTSD group, the scores of positive coping style were positively correlated with the gray matter volumes of the right talus fissure and the lingual gyrus ( P<0.05); the scores of positive coping style, and the gray matter volumes of the right talus fissure and the lingual gyrus were negatively correlated with scores of CAPS-C 5 and CAPS-C ( P<0.05). (3) In the PTSD group, positive coping style can positively predict the gray matter volumes of the right talus fissure and the lingual gyrus; the gray matter volumes of the right talus fissure and the lingual gyrus can negatively predict the avoidance-related symptoms. Conclusion:Positive coping style has influence in the gray matter volumes of the right talar fissure and lingual gyrus of PTSD patients lost their only child; and less positive coping style may affect the brain areas related to visual information processing, thus aggravating avoidance-related symptoms of PTSD patients.
