Research status of neurovascular coupling by photolysis of cage-locking calcium
10.3760/cma.j.cn115354-20220520-00353
- VernacularTitle:应用光解笼锁钙技术研究神经血管耦联的现状
- Author:
Yuncong LI
1
;
Yongjin ZHANG
;
Fei WANG
Author Information
1. 昆明医科大学第一附属医院神经外科，昆明 650032
- Keywords:
Neurovascular coupling;
Caged calcium;
Uncaging calcium
- From:
Chinese Journal of Neuromedicine
2022;21(9):945-950
- CountryChina
- Language:Chinese
-
Abstract:
Calcium ions play an important role in neurovascular coupling, an important neural microcircuit that regulates blood supply to meet the energy and oxygen requirements for neuronal activation. Sequestering intracellular calcium in a photochemically unstable compound (calcium cage) is called caged calcium. On the contrary, uncaging calcium technology is the opposite process against caged calcium and works by releasing free calcium from calcium cage in the presence of light with certain wavelength. Therefore, uncaging calcium is an effective tool by enabling the manipulation of calcium in time, space and concentration freely. Based on the uncaging calcium technology, this paper reviews the application of such technology in the studies of neurovascular coupling to provide more convenient tools and increase the feasibility of research in calcium ion related scientific problems in the neurovascular coupling field.
