Recent advance in hypoxia inducible factors affecting iron metabolism to regulate iron overload in nervous system
10.3760/cma.j.cn115354-20220523-00360
- VernacularTitle:缺氧诱导因子影响脑铁代谢调控神经系统铁超载的机制研究进展
- Author:
Zhiwei ZHANG
1
;
Tianlei ZHANG
;
Mingchu FANG
;
Xinru LIN
;
Haizhe LI
;
Zhenlang LIN
Author Information
1. 温州医科大学第二临床医学院，温州 325006
- Keywords:
Brain iron metabolism;
Brain iron overload;
Hypoxia inducible factor;
Nervous system;
Oxidative stress
- From:
Chinese Journal of Neuromedicine
2022;21(8):843-846
- CountryChina
- Language:Chinese
-
Abstract:
Iron overload, as a pathological feature of many nervous system diseases, can cause oxidative stress and lead to abnormal iron metabolism and injury of nerve cells. Hypoxia inducible factor (HIF) can participate in brain iron metabolism by regulating brain iron uptake, storage, excretion and intracellular regulation. So, HIF is expected to become a therapeutic target to inhibit brain iron overload in nervous system diseases. This paper reviews the physiological/pathological mechanism of HIF in regulating brain iron metabolism, in order to provide new treatment ideas and methods for nervous system diseases characterized by brain iron overload.
