Research status of molecular mechanisms of reactive astrocytes in progress and treatment of Alzheimer's disease

VernacularTitle:反应性星形胶质细胞在AD进展及治疗中的分子机制研究现状
Author: Xiaoxu GUO ¹ ; Yuheng JIN ; Chenyang WANG ; Wenjing ZHAO ; Yang LI
Author Information

1. 南方医科大学第二临床医学院，广州　510282
Keywords: Alzheimer's disease; Reactive astrocyte; Beta-amyloid
From: Chinese Journal of Neuromedicine 2022;21(8):837-842
CountryChina
Language:Chinese
Abstract: In recent years, it has been found that reactive astrocytes (RAS) can affect the pathological process of AD through various mechanisms, such as increasing the production and deposition of β-amyloid (Aβ), aggravating the neurotoxicity of Aβ and disturbance of neurotransmitter release. Currently, the mechanism of drug treatment for AD is mainly targeted at clearance of Aβ, but the efficacy is still uncertain. Recent studies have shown that most AD-related genes are obviously expressed in RAS. Therefore, regulating the morphology and function of RAS through drug intervention may provide new ideas for treatment of AD. The authors review the research status in the molecular mechanism of RAS in the progress and treatment of AD, in order to provide more references for RAS as a target in the prevention and treatment of AD.