Recent advance in role of pyroptosis in sepsis-associated encephalopathy

VernacularTitle:细胞焦亡在脓毒症相关性脑病中的研究进展
Author: Yuqi CAI ¹ ; Yuzi JIN ; Xiaoqing JING
Author Information

1. 承德医学院附属医院小儿内科，承德　067000
Keywords: Sepsis; Sepsis associated encephalopathy; Pyroptosis
From: Chinese Journal of Neuromedicine 2022;21(7):735-739
CountryChina
Language:Chinese
Abstract: Sepsis associated encephalopathy (SAE) is a serious complication of sepsis. The occurrence of SAE often indicates poor prognosis of the patients. SAE pathogenesis is complex, and pyroptosis is involved in the neuroinflammation, oxidative stress and mitochondrial autophagy in SAE. This paper reviews the relations of pyroptosis with key factors in the above process (P2X7 receptor, nuclear factor erythroid-2-related factor 2 and adenosine monophosphate-activated protein kinase) and pyroptosis related regulators to provide references for the diagnosis and treatment of SAE.