Recent advance in pathogenesis of oligodendrocyte progenitor cells in neurodegenerative diseases
10.3760/cma.j.cn115354-20211209-00802
- VernacularTitle:少突胶质细胞祖细胞在神经退行性疾病发病机制中的作用研究进展
- Author:
Xiuzhao YANG
1
;
Tianyuan YE
;
Dongmei QI
;
Xiaorui CHENG
Author Information
1. 山东中医药大学药学院，济南 250300
- Keywords:
Oligodendrocyte progenitor cell;
Myelin;
Multiple sclerosis;
Alzheimer's disease
- From:
Chinese Journal of Neuromedicine
2022;21(7):727-734
- CountryChina
- Language:Chinese
-
Abstract:
Oligodendrocyte progenitor cells are distributed throughout the central nervous system and can proliferate, migrate and differentiate into oligodendrocytes. The core function of oligodendrocytes is to produce myelin, form a myelin sheath, wrap the axons, and increase the conduction rate of neurons. Recent studies have shown that large numbers of oligodendrocyte progenitor cells exist in the lesions of neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease, and these cells play an important role in the repair of neurological damage. The physiological functions of oligodendrocyte progenitor cells and their roles in neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease are reviewed in order to provide a new idea and direction for the research and treatment of neurodegenerative diseases.
