Systemic immune-inflammation index and monocyte to high-density lipoprotein cholesterol ratio in clinical efficacy evaluation of transcranial direct current stimulation in patients with delayed encephalopathy due to carbon monoxide poisoning
10.3760/cma.j.cn115354-20220425-00270
- VernacularTitle:SII和MHR在经颅直流电刺激治疗一氧化碳中毒迟发性脑病患者疗效评价中的应用
- Author:
Hongna QI
1
;
Jia LI
;
Fantuo KONG
;
Weizhan WANG
;
Pu WANG
Author Information
1. 河北医科大学哈励逊国际和平医院急救医学部，衡水 053000
- Keywords:
Delayed encephalopathy after carbon monoxide poisoning;
Transcranial direct current stimulation;
Systemic immune-inflammation index;
Monocyte to high-den
- From:
Chinese Journal of Neuromedicine
2022;21(7):684-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the changes of blood systemic immune-inflammation index (SII) and monocyte to high-density lipoprotein cholesterol ratio (MHR) in patients with delayed encephalopathy after carbon monoxide poisoning (DEACMP) accepted transcranial direct current stimulation (tDCS) treatment, and to objectively evaluate the efficacy of tDCS in DEACMP.Methods:A total of 80 DEACMP patients admitted to our hospital from January 2020 to February 2022 were selected and randomly divided into observation group ( n=39) and routine group ( n=41). Conventional treatment was given to patients of both groups. On this basis, tDCS was given additionally to the observation group: the left dorsolateral prefrontal lobe was used as the positive stimulation site, and the right shoulder was used as the negative stimulation site; the treatment duration was 30 min/time, and the stimulation intensity was 1.5 mA, once per d; and sham stimulation was given to the routine group: the electrodes were stimulated with 1.5 mA current for 10 s and kept for 30 min, once per d. Patients of both groups were treated for 4 weeks. Before, and 4 weeks and 6 months after treatment, SII and MHR were detected; the electroencephalogram (EEG) results, and scores of Montreal Cognitive Assessment (MoCA) and activities of daily living (ADL) were observed. The total effective rate between the 2 groups after 4 weeks of treatment (total effective rate [%]=[number of cured cases+number of improved cases]/total number of cases×100%), and the correlations of SII and MHR before treatment with ADL scores and abnormal degree of EEG were analyzed. Results:The total effective rate in the observation group (92.3%, 30 were cured and 6 got improvement) was significantly higher than that in the routine group (73.2%, 22 were cured and 8 got improvement; χ2=5.070, P=0.024). Four weeks and 6 months after treatment, SII, MHR, abnormal rates of EEG and P300 latency in the observation group were significantly lower than those in the routine group, and the MoCA and ADL scores and P300 amplitude were statistically higher than those in the routine group ( P<0.05). Correlation analysis showed that SII and MHR before treatment were negatively correlated with ADL scores ( r=-0.805, P<0.001; r=-0.788, P<0.001); SII and MHR were positively correlated with abnormal degree of EEG ( r=0.803, P<0.001; r=0.719, P<0.001). Conclusion:The tDCS treatment can effectively reduce the inflammation levels and improve prognosis scores in DEACMP patients; SII and MHR can preliminarily evaluate the therapeutic effect of tDCS.
