Recent advance in dizocilpine MK-801 animal models of schizophrenia
10.3760/cma.j.cn115354-20210924-00623
- VernacularTitle:精神分裂症MK-801动物模型的研究进展
- Author:
Boyin ZHANG
1
;
Yuying CAO
;
Jiayue MA
;
Yunfan ZHAO
;
Chunyue HUO
Author Information
1. 首都医科大学燕京医学院，北京 101300
- Keywords:
Schizophrenia;
Dizocilpine;
Glutamate;
Animal model
- From:
Chinese Journal of Neuromedicine
2022;21(6):642-645
- CountryChina
- Language:Chinese
-
Abstract:
Schizophrenia (SCZ) is a kind of devastating and common neuropsychiatric disorder, and its etiology remains to be determined. Dizocilpine MK-801 animal models, which can cover the major endophenotypes of SCZ, are widely used in the study of SCZ. In this paper, the research status is reviewed about the pathogenic mechanism, modeling method, behavioral characteristics of MK-801 animal models of SCZ in recent years in order to provide some possible ideas for the study of SCZ.
