Recent advance in abnormal neuronal and astrocytic calcium signalw involved in Alzheimer's disease progression
10.3760/cma.j.cn115354-20211211-00808
- VernacularTitle:神经元和星形胶质细胞钙信号异常参与阿尔茨海默病研究进展
- Author:
Zhenjie TUO
1
;
Yuanjie ZHAO
;
Peijun SHANG
;
Jinwen YANG
;
Xiaohua ZHANG
Author Information
1. 西安医学院公共卫生学院，西安 710021
- Keywords:
Alzheimer's disease;
Calcium signal;
Neuron;
Astrocyte
- From:
Chinese Journal of Neuromedicine
2022;21(6):624-628
- CountryChina
- Language:Chinese
-
Abstract:
In the brains of patients with Alzheimer's disease (AD) or AD animal models, β-amyloid (Aβ), tau protein, presenilin (PS)1, PS2 and apolipoprotein E4 (ApoE4) would affect the calcium channels on neuronal cell membrane, endoplasmic reticulum membrane and mitochondrial membrane, and eventually lead to the imbalance of calcium homeostasis in neurons. Aβ can also act on the endoplasmic reticulum of astrocytes and cause abnormal calcium signal. Abnormal calcium signals in the brain in turn act on neurons and promote Aβ and tau protein phosphorylation, which aggravates the disease. This study focuses on the changes of calcium signals in neurons and astrocytes in AD, in order to clarify the relationship between the calcium dyshomeostasis in neurons and astrocytes and the pathogenesis of AD, thus provides new idea for the prevention and treatment of AD.
