Recent advance in sleep-wake regulation of parvalbumin positive neurons

VernacularTitle:小清蛋白阳性神经元调节睡眠-觉醒的研究进展
Author: Dan LUO ¹ ; Rulan YI ; Yu ZHANG
Author Information

1. 遵义医科大学研究生院，遵义　563099
Keywords: Parvalbumin positive neuron; Sleep-wake; Basal forebrain; Thalamic reticular nucleus; Cortex
From: Chinese Journal of Neuromedicine 2022;21(6):619-623
CountryChina
Language:Chinese
Abstract: Parvalbumin (PV) positive neurons, as one of the most important subtypes of γ-aminobutyric acid (GABA) inhibited interneurons, are widely distributed in various brain regions. Previous studies have found that PV positive neurons are closely related to epilepsy, schizophrenia, depression, autism, Alzheimer's disease, ataxia, and morphine dependence and withdrawal. However, recent studies have found that PV positive neurons also play an important role in sleep-wake regulation, suggesting that PV positive neurons may also play an important role in the process of consciousness loss and consciousness recovery induced by general anesthesia. This review focuses on the biological characteristics of PV positive neurons and the research progress of sleep-wake regulation in different brain regions, in order to provide new ideas for the study of mechanism of consciousness loss and consciousness recovery induced by general anesthesia.