Cerebral microcirculation disorder caused by microglia in inflammatory state and its pathogenic effect
10.3760/cma.j.cn115354-20210926-00630
- VernacularTitle:炎症状态下小胶质细胞引起的脑微循环障碍及其致病作用的研究进展
- Author:
Long LIN
1
;
Xiangrong CHEN
;
Shousen WANG
Author Information
1. 福建医科大学福总临床医学院神经外科，福州 350025
- Keywords:
Microglia;
Neurovascular unit;
Cerebral microcirculation;
Neuroinflammation;
Nervous system disease
- From:
Chinese Journal of Neuromedicine
2022;21(5):511-515
- CountryChina
- Language:Chinese
-
Abstract:
Microglia are the main immune cells of the central nervous system and an important part of neurovascular unit (NVU). Together with endothelial cells, pericytes, vascular smooth muscle cells, astrocytes and neurons, microglia form NVU. They play an important role in maintaining the integrity of blood-brain barrier (BBB), regulating cerebral blood flow (CBF) and maintaining basic brain function. Neuroinflammation mediated by microglia can lead to cerebral circulation disorder, which is related to the occurrence and development of a variety of nervous system diseases. This paper reviews the characteristics and subtypes of microglia, the relations of microglia with brain microinflammation and cerebral microcirculation, and the correlation of microglia with central nervous system diseases.
