Meta analysis of Wuling capsules in insomnia treatment
10.3760/cma.j.cn115354-20220228-00105
- VernacularTitle:乌灵胶囊治疗失眠症疗效的Meta分析
- Author:
Ling WANG
1
;
Dandan WANG
;
Daoyou ZHOU
Author Information
1. 广州中医药大学第二临床医学院，广州 510000
- Keywords:
Wuling capsule;
Insomnia;
Randomized controlled trial;
Meta analysis
- From:
Chinese Journal of Neuromedicine
2022;21(5):492-498
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the clinical efficacy of Wuling capsules in the treatment of insomnia.Methods:The randomized controlled trial (RCT) literature related to the treatment of insomnia with Wuling capsules was searched by computer through PubMed, EMbase, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Wanfang, and VIP databases. These RCT literature was searched by using "Wuling capsule and Insomnia" as keywords, and the search time frame was from the establishment of each database to January 2022. The literature was screened and relevant data were collected according to the designed nesting criteria (patients accepted conventional western medicines such as benzodiazepines or new non-benzodiazepines were used as control group, and patients accepted Wuling capsules alone or combined with conventional western medicines were used as study group; the outcome measures included total response rate, total scores of Pittsburgh Sleep Quality Index or Sleep Disorders Rating Scale), and Meta-analysis was performed on the extracted literature data using Revman 5.4 software.Results:A total of 17 pieces of RCT literature met the criteria were finally included, with a total of 1493 patients, including 749 patients into the study group and 744 patients into the control group. The overall efficiency of the study group was significantly higher than that of the control group (relative risk [ RR]=1.270, 95%CI: 1.200-1.340, P<0.05), and total scores of Pittsburgh Sleep Quality Index scale in study group were significantly lower than those in the control group (weighted mean difference [ WMD]=-2.070, 95%CI: -2.610--1.520, P<0.05), and the total scores of Sleep Disorder Rating Scale in study groups were significantly lower than those in the control group ( WMD=-4.180, 95%CI: -4.900--3.450, P<0.05). Conclusion:The efficacy of Wuling capsules alone or combined with conventional western medicines in treating insomnia is better than that of conventional western medicines, and can obviously improve the quality of sleep of patients.
