Clinical and basic research progress of adrenocorticotropic hormone in treatment of infantile spasm

VernacularTitle:促肾上腺皮质激素治疗婴儿痉挛症的临床和基础研究进展
Author: Yan ZHANG ¹ ; Xinna JI ; Qian CHEN
Author Information

1. 首都儿科研究所附属儿童医院神经内科，北京　100020
Keywords: Infantile spasm; Adrenocorticotropic hormone; Mechanism; Research progress
From: Chinese Journal of Neuromedicine 2022;21(4):420-424
CountryChina
Language:Chinese
Abstract: Infantile spasm (IS) is a common epileptic encephalopathy in infancy, characterized by typical epileptic spasm, developmental delay and hypsarrhythmia on interictal electroencephalogram (EEG). Adrenocorticotropic hormone (ACTH) is the first-line treatment medicine for IS. Although ACTH has shown good response to IS and has been widely used, the regime is not identical and the mechanism is still unclear. This paper focuses on the clinical application of ACTH for IS and the anticonvulsant mechanisms of ACTH, in order to provide clinical and theoretical basis for ACTH application.